Friedrich Schiedel endowed chair of neuroscience, Dept. of Medicine, Technische Universität München, Germany
Synaptic Physiology and Plasticity
Title of the talk:
Neuronal circuit dysfunction in Alzheimer’s mouse models In vivo.
Arthur Konnerth’s current research is concentrated on a better understanding of the mechanisms underlying brain function in health and disease. His lab studies different types of neurons and circuits in the cortex, cerebellum and hippocampus, and uses a variety of techniques, including electrophysiology, molecular biology, optogenetics, behavioral analyses and high-resolution optical imaging. A major focus of the work is directed towards an exploration of behavior-determined synaptic signaling and dendritic integration in neurons of defined circuits in vivo. Another focus of the lab is the exploration of the mechanisms underlying neuronal dysfunction in Alzheimer’s disease. He and his team pioneered in vivo two-photon imaging of cortical circuits with single cell resolution. More recently, they developed the LOTOS method of high-resolution two-photon imaging and used it for the first time functional mapping of dendritic spines in vivo.