European Neuroscience Institute, Germany
Title of the talk:
Motor neuron functional diversification and movement control in the mouse
Till Marquardt is head and principal investigator of the Developmental Neurobiology Laboratory at the European Neuroscience Institute (ENI-G), which is affiliated with the University Medical Center Göttingen and the Max-Planck Society. He is currently recipient of a European Research Council (ERC) consolidator grant and is a past recipient of an Emmy Noether starting grant. During his Ph.D. he worked on the genetic regulation of eye development with Peter Gruss at the Max-Planck Institute of Biophyiscal Chemistry. He subsequently joined the group of Sam Pfaff at the Salk Institute of Biological Studies, where he studied membrane signaling complexes regulating axon navigation. He was recipient of Damon Runyon and Pioneer Fund Fellowship awards. Since starting his own group at the ENI in 2007 his work focuses on mechanisms driving neuron functional diversification and its contribution to movement control, as well as axon-axon and axon-glia signaling underlying neural circuit assembly and pathology in the mouse.
The group of Till Marquardt exploits the unique position of the neuromuscular and peripheral nervous systems at the interface of brain and body to link aspects of neural wiring and firing to readily measurable outputs to movement apparatus or organ function. This entails resolving the molecular machineries promoting motor neuron functional diversification and its contribution to movement control (project area I) and the dissection of axon-axon and axon-glia signaling pathways underlying peripheral circuit assembly or pathology (project area II). These studies involve a combination of cell biological, genetic/optogenetic, electrophysiology and behavioral analysis in the mouse.