University of Medicine, Göttingen
Molecular Neuroscience and Neurogenetics
Title of talk:
Re-routing of the Calcium-Sensing-Receptor from recycling to late endosomes by TrkB enhances BDNF-mediated neurite growth
One of the most intensely studied areas in biology is how neurons establish and maintain functional neural circuits. However, the precise molecular mechanisms of this regulation and how neurons maintain their circuits in vivo remain incompletely understood.
Dr. Burk’s main scientific interest is to understand and decipher trafficking mechanisms as part of these underlying mechanisms. Her team investigates activated receptor trafficking during development, when axons navigate through their environment and connect with their respective targets but also in disease context such as Parkinson’s disease, frontotemporal dementia and Charcot- Marie-Tooth, where functional receptors fail to traffic correctly.
The lab addresses the following questions:
– What are the mechanisms of activated receptor sorting and can receptors re-route?
– Which proteins are regulating the intracellular sorting machineries and how does dysfunction of these proteins lead to neurological diseases?
– What are the exact dynamics of endosomes during activated receptor sorting and are these dynamics compromised in disease states?
Dr. Burk’s group uses an interactome and biochemistry approach as well as live-cell and high-resolution imaging to investigate these questions. In addition, they study endogenous dynamics using CRISPR in iPSC- lines from patients.