The overarching goal of Jayeeta Basu’s research program is to identify synaptic and circuit-based mechanisms supporting spatial navigation and experience dependent formation, stabilization and flexibility of long-term memory representations. These are critical functions of the brain enabling adaptive learnt behaviors. They focus on cortico-hippocampal circuit interactions using electrophysiology and two-photon imaging combined with optogenetic manipulations and behavioral analysis. Hippocampal and entorhinal cortex dysfunction has been implicated in the pathophysiology of neurological disorders, especially Alzheimer’s disease, and epilepsy. A major aim for their research is to identify the cellular changes that manifest in these disease states and find potential therapeutic targets for intervention.