The goal of Dr. Denise Cai’s research is to understand how memories are stored and updated across time and experience. She investigates the neural mechanisms governing these complex processes with a multi-level approach, combining cellular, systems, and behavioral techniques.
In a first line of inquiry, they are building on their novel characterization of the role of intrinsic neuronal excitability in the linking of memories across time in young and older mice (Cai et al., Nature, 2016). In collaboration with Sara Mednick, PhD, they also showed the first human behavioral evidence for temporal memory-linking (Yetton et al., Frontiers in Human Neuroscience, 2019). Memory-linking is particularly important in the context of such disorders as PTSD, as alterations in memory-linking could have severe consequences for cognition. The Cai lab recently published three papers on related themes (Mau et al., eLife, 2020; Sweis et al., Current Opinion in Neurobiology; Chen L, et al., 2020 Neurobiology of Learning and Memory, 2020). An associated line of inquiry explores the how memories are stabilized and integrated with past experiences during sleep.
In a second line of investigation, they are exploring the mechanisms by which the brain optimizes its capacity to store information across a lifetime. These studies are supported by an NIH Director Innovator’s Award.
Dr. Cia’s lab also develops and disseminates open-source neurotechnology. She is one of the primary developers of the open-source Miniscopes for in vivo calcium imaging (Cai et al., Nature, 2016; Shuman et al., 2020). They recently published a pipeline for behavior tracking (ezTrack) and a miniscope analysis pipeline (Pennington et al., Science Reports, 2019; Dong, et al., bioRxiv, 2021, Pennington et al., Current Protocols, in press). In collaboration with others at Mount Sinai and other institutions, they continue to develop new imaging tools and related software to be openly shared with the larger neuroscience community.