Understanding how dream mentation and ambulation arise from sleep’s basic physiological components has enticing, and potentially wide-reaching basic neuroscientific and translational clinical implications. The first case in point is the rapid eye movement (REM) behaviour disorder (RBD), a relatively rare parasomnia that predicts later occurrence of alpha-synucleinopathies such as Parkinson disease (PD), multiple system atrophy and dementia with Lewy bodies. Unlike sleep-walkers, patients with rapid-eye-movement-behaviour disorder (RBD) rarely leave the bed during the re-enactment of their dreams. RBD movements may be independent of spatial co-ordinates of the ‘outside-world’, and instead rely on (allocentric) brain-generated virtual space-maps, as evident by patients’ limited truncal/axial movements. The second case in point is dreaming of congenitally blind people whose dreams surprisingly may comprise visual imagery, not dissimilar to that or normally sighted people. During my talk, I will address the potential underlying mechanisms of these and discuss what future studies should include to answer many of the unresolved conundrums.