Ivan Manzini

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Institute of Neurophysiology and Cellular Biophysics


Sensory and Motor Systems

Title of the talk:
Parallel processing of sulfated steroid odorants in the olfactory system of an anuran amphibian



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1980-1993 School attendance in Bozen/Bolzano, Italy
1993-1999 Studies of Biological Sciences at the University of Modena and Reggio Emilia, Modena, Italy
1999-2000 Doctoral Thesis at the Institute of Physiology, University of Göttingen, Göttingen, Germany
2000-2003 Continuation and Completion of the Doctoral Thesis within the MSc/PhD/MD-PhD Neuroscience Program of the University of Göttingen, Göttingen, Germany



2003-2010 Research Assistant (Postdoctoral Research Fellow) at the Institute of Physiology, University of Göttingen, Göttingen, Germany
since 2011 Research Group Leader at the Institute of Physiology, University of Göttingen, Göttingen, Germany



1999-2001 Ph.D. Scholarship within the DFG Research Training Group 225 (Graduiertenkolleg 225) ‘Organisation and Dynamics of Neuronal Networks’, University of Göttingen, Göttingen, Germany
2006 DFG Travel Award (28th Annual Meeting of the Association for Chemoreception Sciences – AChemS)
2009 Polak Young Investigator Award (Association for Chemoreception Sciences)



1. Sansone, A., A.S. Syed, E. Tantalaki, S.I. Korsching, and I. Manzini. 2014. Trpc2 is expressed in two olfactory subsystems, the main and the vomeronasal system of larval Xenopus laevis. J. Exp. Biol. 217:2235-2238.

2. Hassenklöver, T., and I. Manzini. 2013. Olfactory wiring logic in amphibians challenges the basic assumptions of the unbranched axon concept. J .Neurosci. 33:17247-17252.

3. Syed, A.S., A. Sansone, W. Nadler, I. Manzini, and S.I. Korsching. 2013. Ancestral amphibian v2rs are expressed in the main olfactory epithelium. Proc .Natl. Acad. Sci. USA 110:7714-7719.

4. Gliem, S., A.S. Syed, A. Sansone, E. Kludt, E. Tantalaki, T. Hassenklöver, S.I. Korsching, and I. Manzini. 2013. Bimodal processing of olfactory information in an amphibian nose: Odor responses segregate into a medial and a lateral stream. Cell. Mol. Life Sci. 70:1965-1984.

5. Breunig, E., I. Manzini, B. Gutermann, D. Schild, and D. Czesnik. 2010. The endocannabinoid 2-AG controls odor sensitivity in larvae of Xenopus laevis. J. Neurosci. 30:8965-8973.

6. Hassenklöver, T., P. Schwartz, D. Schild, and I. Manzini. 2009. Purinergic signaling regulates cell proliferation of olfactory epithelium progenitors. Stem Cells 27:2022- 2031.

7. Hassenklöver, T., S. Kurtanska, I. Bartoszek, S. Junek, D. Schild, and I. Manzini. 2008. Nucleotide-induced Ca2+ signaling in sustentacular supporting cells of the olfactory epithelium. Glia 56:1614-1624.

8. Czesnik, D., D. Schild, J. Kuduz, and I. Manzini. 2007. Cannabinoid action in the olfactory epithelium. Proc. Natl. Acad. Sci. USA 104:2967-2972.

9. Manzini, I., and D. Schild. 2004 Classes and narrowing selectivity of olfactory receptor neurons of Xenopus laevis tadpoles. J. Gen. Physiol. 123:99-107.

10. Manzini, I., and D. Schild. 2003. Multidrug resistance transporters in the olfactory receptor neurons of Xenopus laevis tadpoles. J. Physiol. 546:375-385.


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The research of my group is directed towards a better understanding of how the olfactory network is formed during development and maintained in the adult. We study how individual neurons develop and how they integrate into neuronal circuitry. We also set out to elucidate the molecular and cellular mechanisms of olfactory coding. Our animal model is the African clawed frog Xenopus laevis. Amphibian species represent an evolutionary intermediary between fishes and mammals and are, therefore, particularly suited to study questions related to the evolution of the vertebrate olfactory system.


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