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Institute:
CNRS UMR, Paris, France
Website:
http://www.ibps.upmc.fr/en/ibps/directory/1167-Bruno-Cauli
Session:
Systems, Circuits and Computation
Title of the talk:
Neurogenic control of neurovascular coupling.
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Research
The cerebral cortex comprises diverse areas involved in perception, movement or cognition. In spite of this functional diversity, the cortical network is formed with the repetition of a microcircuit. This microcircuit contains excitatory and inhibitory neuronal types. The neuronal activity of this microcircuit, its local cerebral blood flow and metabolism are tightly coupled to match the increased energy needs occurring during neuronal processing. This neurovascular and neurometabolic coupling, essential to normal brain function and integrity, is also the physiological basis of the hemodynamic contrasts widely used to map neuronal activity in health and disease. A major goal of Bruno Cauli’s laboratory is to understand how the microcircuit controls its own energy supply and metabolism via interactions with the glio-vascular network. These points are addressed at the molecular, cellular and network levels in rodent cortical slices. Patch-clamp electrophysiology often combined with single cell RT-PCR and histochemistry is the central methodology of the lab. Viral transfer or transgenic mice are also used to express various genes of interest in cell types. Among these genes, the light-operated channelrhodopsin are used to excite specific neuronal types and evaluate their influence on the glio-vascular network. Diverse bioluminescent or fluorescent genetically-encoded sensors are also to image metabolic activities at the cellular and multicellular levels.
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Biography
Professional Experience
2001-2002 Junior staff scientist (CR2), CNRS UPR 2216, Gif-sur-Yvette, France
2002-2005 Junior staff scientist (CR2), CNRS UMR 7637, Paris, France
2005-2007 Established scientist, Team leader (CR1), CNRS UMR 7637, Paris, France
2008-2013 Established scientist, Team leader (CR1), CNRS UMR 7102, Paris, France
2014-Present Research director, Team leader (DR2), CNRS UMR 8246 Paris, France
Fellowships and Awards
2007 Human Frontier of Science Program Young Investigator Award
2007 CNRS Bronze Medal
Selected peer-reviewed publications
- Lacroix A, Toussay X, Anenberg E, Lecrux C, Ferreiros N, Karagiannis A, Plaisier F, Chausson P, Jarlier F, Burgess SA, Hillman EMC, Tegeder I, Murphy TH, Hamel E, Cauli B. COX-2-Derived prostaglandin E2 produced by pyramidal neurons contributes to neurovascular coupling in the rodent cerebral cortex. J. Neurosci. Aug 35(34): 11791-11810 (2015).
- Lecrux C, Toussay X, Kocharyan A, Fernandes P, Lévesque M, Plaisier F, Cauli B, Hamel E. Pyramidal neurons are “neurogenic hubs”in the neurovascular coupling response to whisker stimulation. J. Neurosci. 2011 Jul 6;31(27):9836-47.
- Karagiannis A, Gallopin T, Dávid C, Battaglia D, Geoffroy H, Rossier J, Hillman EM, Staiger JF, Cauli B. Classification of NPY-expressing neocortical interneurons. J Neurosci. Mar 18;29(11):3642-59 (2009).
- Petilla Interneuron Nomenclature Group, Ascoli GA, Alonso-Nanclares L, Anderson SA, Barrionuevo G, Benavides-Piccione R, Burkhalter A, Buzsáki G, Cauli B, Defelipe J, Fairén A, Feldmeyer D, Fishell G, Fregnac Y, Freund TF, Gardner D, Gardner EP, Goldberg JH, Helmstaedter M, Hestrin S, Karube F, Kisvárday ZF, Lambolez B, Lewis DA, Marin O, Markram H, Muñoz A, Packer A, Petersen CC, Rockland KS, Rossier J, Rudy B, Somogyi P, Staiger JF, Tamas G, Thomson AM, Toledo-Rodriguez M, Wang Y, West DC, Yuste R. Petilla terminology: nomenclature of features of GABAergic interneurons of the cerebral cortex. Nat Rev Neurosci. Jul;9(7):557-68. (2008).
- Rancillac A, Rossier J, Guille M, Tong XK, Geoffroy H, Amatore C, Arbault S, Hamel E, Cauli B. Glutamatergic Control of Microvascular Tone by Distinct GABA Neurons in the Cerebellum. J Neurosci. Jun 28;26(26):6997-7006 (2006).
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