Medical Faculty of the University and the German Cancer Research Center (DKFZ) Heidelberg, Germany
Synaptic Physiology and Plasticity
Title of the talk:
Inhibition in the brain and its function for network synchronization and neurogenesis.
Hannah Monyer has studied GABAergic interneurons linking the molecular, cellular and behavioral level. She generated mice in which properties of selective GABAergic interneurons were altered in a cell-type specific fashion to reveal the functional implication for hippocampus-dependent learning and memory. Her current focus of research includes investigations on long-range GABAergic neurons in several forebrain regions, in particular in the context of network synchrony, spacial coding and memory. Ongoing projects address the question as to the cellular identity of neurons within microcircuits of the entorhinal cortex, and whether grid cells are the cellular substrate for path integration.
Another focus of research regards the function of GABAergic signalling and its modulation for postnatal neurogenesis. Hannah Monyer and her colleagues identified DBI (Diazepam binding inhibitor) as a key modulator for stem cell and transient amplifying cell proliferation. Current research revolves around the questions how the reduced GABA signalling induced by DBI regulates symmetric cell division and whether and how enriched environment affects DBI modulation of postnatal neurogenesis.