Jakub Vohryzek (Deco lab) | “Whole-brain digital twins: modelling and perturbing brain dynamics in health and disease”
Theoretical and computational neuroscience \ Manfred Eigen lecture theatre
Whole-brain computational models provide a framework for linking structural connectivity with large-scale brain dynamics. In this talk, I will present recent work using neuroimaging-informed dynamical models to reproduce and perturb functional brain activity, forming the basis for “digital twins” of individual brains. By combining generative modelling with empirical data, these models can reveal mechanistic principles governing brain dynamics and predict how network activity changes in neurological disorders. I will discuss applications to conditions such as stroke and Alzheimer’s disease, as well as ongoing efforts within large collaborative projects to develop personalized models that may guide targeted neuromodulation and therapeutic interventions.