Michael Grange

Cellular and molecular neuroscience session | The title of the talk is not defined yet.

Michael Grange is a structural biologist whose research bridges molecular imaging and neurobiology to uncover the mechanisms underlying neurodegenerative disease.

He earned his D.Phil. in Structural Biology from the University of Oxford, where he used in-cell structural techniques to study viral trafficking and egress. As an EMBO Long-Term Fellow at the Max Planck Institute for Molecular Physiology, he developed high-throughput FIB-milling and molecular imaging workflows to analyze mammalian muscle and stem-cell-derived cardiomyocytes.

His current group pioneers advanced light and electron microscopy approaches to achieve high-resolution imaging of native tissue, aiming to map molecular changes in the brain across synaptic types. Focused on disorders such as Alzheimer’s disease, his team investigates how Tau fibrils alter cellular and synaptic integrity. Through innovations in large-volume tomography, cryogenic biochemical microscopy, and structural neurobiology, Dr. Grange’s work is transforming our molecular understanding of brain organization and disease progression.