Susana Castro Obregón | “Molecular basis for autophagy dysfunction and neuronal senescence”

Cellular and molecular neuroscience \ Manfred Eigen lecture theatre

A main hallmark of aging in several species is autophagy dysfunction, and pharmaceutical or genetic interventions that improve its function delay aging symptoms. Yet, why autophagy becomes dysfunctional with age is still poorly understood. We discovered that neuronal senescence is caused by autophagic flux impairment, which seems to be based on an exacerbated nuclear-cytoplasmic transport.

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