The Edmond and Lily Safra Center for Brain Sciences (ELSC)
Molecular Neuroscience and Neurogenetics
Title of talk:
The impact of non-coding RNAs on cholinergic reactions to trauma (tentative)
Dr Hermona Soreq was trained at The Weizmann Institute of Science and the Rockefeller University. She joined the faculty of The Hebrew University in 1986, where she holds a University Slesinger Chair and is a founding member of the Edmond and Lily Safra Center for Brain Science. Dr Soreq’s research pioneered the application of molecular biology and genomics to the study of cholinergic signaling, with a recent focus on its microRNA regulation and on signaling changes in health and disease. She is the elected head of the International Organization of Cholinergic Mechanisms, and served as the elected Dean of the Faculty of Science from 2005-2008. Dr Soreq authored hundreds of publications, including 55 published in Science, Nature, PNAS and other high-impact journals. Dr Soreq studies the molecular regulators of acetylcholine(ACh) functioning with a recent focus on MicroRNAs (miRNAs), which rapidly emerge as global regulators of gene expression, yet the full scope of their roles in brain and body functioning is largely unknown. She combines advanced sequencing technologies with computational neuroscience and transgenic engineering tools to investigate miRNA functions in the healthy and diseased brain, with a focus on acetylcholine-related processes. Her studies discovered cholinergic brain-to-body regulation of anxiety and found “CholinomiR” miRNA silencers of multiple genes that compete with each other on suppressing anxiety and metabolic targets.